乳腺肿瘤内科科主任佟仲生

佟仲生，天津医科大学肿瘤医院 乳腺肿瘤内科科主任，主任医师， 硕士生导师。

任中国抗癌协会靶向治疗专业委员会常委、中国乳腺癌专业委员会委员，天津市抗癌协会化疗专业委员会主任委员、医药学专家协会肿瘤专业委员会主任委员、天津医学会肿瘤学分会委员等多项任职。担任《中国肿瘤临床》、《天津医药》、《中华乳腺病杂志》、《中国综合临床》编委。1986 年毕业于天津医科大学医学系获学士学位，2004-2005 年作为访问学者在美国密西根大学基础与临床工作，天津医科大学肿瘤学硕士，从事肿瘤化疗临床与基础研究工作 30 年，具有丰富肿瘤学专业造诣及临床实践经验，为乳腺肿瘤内科治疗的学科带头人，尤精于乳腺癌综合治疗。对乳腺癌的新辅助、辅助及晚期乳腺癌的化学治疗有较深造诣。主持多项抗癌新药的Ⅰ、Ⅱ、Ⅲ期临床研究，参与国际多中心临床工作 30 余项，曾获中华医学会科技进步奖 1 项，市科委科技进步奖 1 项。

目前承担多项国家、市级课题研究，率先开展局部晚期乳腺癌光动力治疗的基础与临床研究，开辟了光动力转化医学研究新领域，并获 2014 年度天津科技进步三等奖。多次受邀参加国内外学术会议大会发言。国内外发表论文 70 余篇，同时承担带教医师进修班教学工作，培养硕士研究生 24 名，目前主要研究方向乳腺癌综合治疗、光动力联合化疗治疗乳腺癌的基础与临床等相关工作。

主要承担课题

晚期乳腺癌综合治疗（天津市抗癌重大专项课题）

抗肿瘤新药小白菊内酯类似物（ACT001）临床前研究（国家肿瘤临床医学研究中心培育项目）

PTPN12/EGFR 信号通路的活化对贝伐单抗治疗三阴乳腺癌疗效的影响及其应用价值的研究（吴阶平医学基金会临床科研专项资助基金）

光动力联合化疗对乳腺癌的杀伤效应及机制研究（天津市应用基础及前沿技术研究计划）

近期发表文章（*为通讯作者）

[1] F Wang, Y Jia, Z Tong*. Comparison of the clinical and prognostic features of primary breast sarcomas and malignant phyllodes tumor[J]. Jpn J Clin Oncol, 2015,45 (2): 146-152.

[2] C Lu, W Wang, Y Jia, X Liu, Z Tong*, B Li*. Inhibition of AMPK/autophagy potentiates parthenolide-induced apoptosis in human breast cancer cells[J]. J Cell Biochem, 2014,115 (8): 1458-1466.

[3] C Lu, LY Zhou, HJ Xu, XY Chen, Z Tong*, XD Liu, YS Jia, Y Chen. RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation[J]. Acta Pharmacol Sin, 2014,35 (7): 929-936.

[4] C Lu, H Xu, X Chen, Z Tong*, X Liu, Y Jia. Irradiation after surgery for breast cancer patients with primary tumours and one to three positive axillary lymph nodes: yes or no?[J]. Curr Oncol, 2013,20 (6): e585-592.

[5] XQ Wei, X Li, XJ Xin, Z Tong*, S Zhang. Clinical features and survival analysis of very young (age<35) breast cancer patients[J]. Asian Pac J Cancer Prev, 2013,14 (10): 5949-5952.

[6] X Chen, X Liu, L Zhang, S Li, Y Shi, Z Tong*. Poorer survival of male breast cancer compared with female breast cancer patients may be due to biological differences[J]. Jpn J Clin Oncol, 2013,43 (10): 954-963.

[7] LH He, Q Ma, YH Shi, J Ge, HM Zhao, SF Li, Z Tong*. CHL1 is involved in human breast tumorigenesis and progression[J]. Biochem Biophys Res Commun, 2013,438 (2): 433-438.

[8] Z Guan, B Xu, ML DeSilvio, Z Shen, W Arpornwirat, Z Tong, V Lorvidhaya, Z Jiang, J Yang, A Makhson, WL Leung, MW Russo, B Newstat, L Wang, G Chen, C Oliva, H Gomez. Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2-overexpressing metastatic breast cancer[J]. J Clin Oncol, 2013,31 (16): 1947-1953.

[9] Q Zhang, Y Lu, Y Ding, J Zhai, Q Ji, W Ma, M Yang, H Fan, J Long, Z Tong, Y Shi, Y Jia, B Han, W Zhang, C Qiu, X Ma, Q Li, Q Shi, H Zhang, D Li, J Zhang, J Lin, LY Li, Y Gao, Y Chen. Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells[J]. J Med Chem, 2012,55 (20): 8757-8769.

[10] Z Tong*, P Miao, T Liu, Y Jia, X Liu. Enhanced antitumor effects of BPD-MA-mediated photodynamic therapy combined with adriamycin on breast cancer in mice[J]. Acta Pharmacol Sin, 2012,33 (10): 1319-1324.

[11] L Zhang, C Hao, G Dong, Z Tong*. Analysis of Clinical Features and Outcome of 356 Triple-Negative Breast Cancer Patients in China[J]. Breast Care (Basel), 2012,7 (1): 13-17.

[12] C Hao, Y Shi, J Yu, X Wei, S Li, Z Tong*. The therapeutic function of the chemokine RANTES on the H22 hepatoma ascites model[J]. Mol Cell Biochem, 2012,367 (1-2): 93-102.

[13] J Li, X Liu, Z Tong*. Clinical features and survival analysis of T1mic, a, bN0M0 breast cancer[J]. Jpn J Clin Oncol, 2012,42 (6): 471-476.

[14] C Hao, S Wei, Z Tong*, S Li, Y Shi, X Wang, ZH Zhu. The effects of RKIP gene expression on the biological characteristics of human triple-negative breast cancer cells in vitro[J]. Tumour Biol, 2012,33 (4): 1159-1167.

[15] T Liu, Z Tong*, L He, L Zhang. Clinicopathological Characteristics and Survival Analysis of 87 Male Breast Cancer Cases[J]. Breast Care (Basel), 2011,6 (6): 446-451.

[16] L Zhang, Z Tong*, S Li, X Ren, B Ren, X Wang, S Cao, C Wang, L He. Quality of Life after Autologous Peripheral Blood Stem Cell Transplantation and High-Dose Chemotherapy in High-Risk Breast Cancer Patients[J]. Breast Care (Basel), 2009,4 (6): 379-386.

编辑： 方方    来源：丁香园